The noncovalent conjugations of human serum albumin (HSA) with MS/AK and the effect on anti-oxidant capacity as well as anti-glycation activity of <i>Monascus</i> yellow pigments
Shufen Wu, Yue Sun, Di Chen, Huanhuan Liu, Zhenjing Li, Mianhua Chen, Changlu Wang, Lei Cheng, Qingbin Guo, Xin Peng
Abstract
, while aminoguanidine (AG, a reference standard) caused only 65% decrease at the same concentration. Although radical scavenging and metal chelating activities could justify the observed anti-glycation activity of Mps, in-depth research on the structures of other functional compounds present in Mps except MS/AK and reaction mechanisms should be performed. Overall, the present study proved that Mps would be promising sources of food-based anti-glycation agents because of their superior inhibitory effect on AGEs.
Topics & Concepts
MonascusGlycationChemistryHuman serum albuminPigmentSerum albuminBiochemistryFermentationOrganic chemistryReceptorMicrobial Metabolism and ApplicationsBiochemical and biochemical processesPhytochemicals and Antioxidant Activities