Characterization of MroQ-Dependent Maturation and Export of the Staphylococcus aureus Accessory Gene Regulatory System Autoinducing Peptide
Madison R. Stock, Liwei Fang, Kaelie R. Johnson, Chance J. Cosgriff, Wei Ping Teoh, Francis Alonzo
Abstract
Gram-positive bacteria produce small autoinducing peptides (AIPs), which act to regulate expression of genes that promote adaptive traits, including virulence. The Gram-positive pathogen Staphylococcus aureus generates a cyclic AIP that controls expression of virulence factors via the accessory gene regulatory (Agr) system. S. aureus strains belong to one of four Agr groups (Agr-I, -II, -III, and -IV); each group harbors allelic variants of AgrD, the precursor of AIP.
Topics & Concepts
BiologyStaphylococcus aureusGeneRegulator geneMicrobiologyPeptideRegulation of gene expressionGeneticsStaphylococcal infectionsComputational biologyBacteriaBiochemistryAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntimicrobial Peptides and Activities