FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells
Jingchun Wang, Huakan Zhao, Lu Zheng, Yu Zhou, Lei Wu, Yanquan Xu, Xiao Zhang, Guifang Yan, Halei Sheng, Rong Xin, Lu Jiang, Juan Lei, Jian Gang Zhang, Yu Chen, Jin Peng, Qian Chen, Shuai Yang, Kun Yu, Dingshan Li, Qichao Xie, Yongsheng Li
Abstract
activating SOCE/NFATc2 pathway; in turn, NFATc2 transcriptionally activates FGF19 expression. Targeting this signaling circuit represents a potential strategy for improving the therapeutic efficacy of HCC.
Topics & Concepts
FGF19Stem cellCancer researchBiologyHomeobox protein NANOGCell biologyCancer stem cellNFATSOX2Signal transductionFibroblast growth factorTranscription factorReceptorGeneticsEmbryonic stem cellGeneInduced pluripotent stem cellFibroblast Growth Factor ResearchKruppel-like factors researchWnt/β-catenin signaling in development and cancer