Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
Pétur O. Heidarsson, Davide Mercadante, Andrea Sottini, Daniel Nettels, Madeleine B. Borgia, Alessandro Borgia, Sinan Kilic, Beat Fierz, Robert B. Best, Benjamin Schuler
Topics & Concepts
ChemistryHistoneBiophysicsIntrinsically disordered proteinsPolyelectrolyteLinkerNucleosomeChromatinStatic electricityMolecular dynamicsChromatosomeChaperone (clinical)Mechanism (biology)KineticsHistone H1Linker DNAProtein structurePlasma protein bindingPosttranslational modificationSelf-assemblyCryo-electron microscopyProtein–protein interactionChemical physicsProtein foldingMolecular biophysicsElectrostaticsRational designGenomics and Chromatin DynamicsProtein Degradation and InhibitorsClick Chemistry and Applications