NEAT1/miR-200b-3p/SMAD2 axis promotes progression of melanoma
Wen‐Jie Zhou, Haoyu Wang, Jie Zhang, Haiying Dai, Zhixian Yao, Zhong Zheng, Mengyan Sun, Ke Wu
Abstract
, we demonstrated that both NEAT1 and SMAD2 could promote the proliferation and invasion of melanoma cells, and these effects were reversed by up-regulating miR-200b-3p. In addition, NEAT1/miR-200b-3p/SMAD2 axis promoted melanoma progression by activating EMT signaling pathway and immune responses. Taken together, the NEAT1/miR-200b-3p/SMAD2 signaling pathway promotes melanoma via activation of EMT, cell invasion and is related with immune responses, which provides new insights into the molecular mechanisms and therapeutic targets for melanoma.
Topics & Concepts
MelanomaCancer researchMedicineCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases