Depletion of langerin<sup>+</sup> cells enhances cutaneous wound healing
Aarthi Rajesh, Gabriella S. Stuart, Nicola C. Real, Jenny Ahn, Allison Tschirley, Lyn M. Wise, Merilyn Hibma
Abstract
Summary Langerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin + cells in wound healing. In this study, the effects of ablation of langerin + cells on healing of a full‐thickness excision wound were investigated using the langerin‐DTR depletable mouse. Strikingly, depletion of langerin + cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin + ‐cell‐depleted group was characterized by enhanced neo‐epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin + cells was associated with increased levels of granulocyte–macrophage colony‐stimulating factor, F4/80 + cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin + cells during wound healing. Therapies that suppress langerin + cells or their function may therefore have utility in progressing the healing of wounds in humans.