Targeting NINJ1-Mediated Plasma Membrane Rupture in Tubular Epithelial Cell Prevents Inflammatory Response in Acute Kidney Injury
Siyan Zhou, Qigang Lan, Xin Wang, Yaqin Wang, Ai-Hong Zhang, Jiachuan Xiong, Liangjing Lv, Yan Li, Ling Nie, Shaozong Qin, Jinrun Zhou, Shuiqin Gong, Shaobo Wang, Yinghui Huang, Jinghong Zhao
Abstract
-phosphorylated ELK1 can protect against AKI and improve AKI prognosis. Collectively, these findings highlight the ELK1-NINJ1 axis as a pivotal regulator of plasma membrane rupture in RTECs upon AKI, suggesting that it may serve as a potential target for AKI treatment and prognosis improvement.
Topics & Concepts
Acute kidney injuryInflammationCell injuryCell biologyInflammatory responseMedicineKidneyCancer researchApoptosisChemistryImmunologyBiologyInternal medicineBiochemistryAcute Kidney Injury ResearchBiomedical Research and Pathophysiology