Case Report: Immune Checkpoint Blockade Plus Interferon-Γ Add-On Antifungal Therapy in the Treatment of Refractory Covid-Associated Pulmonary Aspergillosis and Cerebral Mucormycosis
Alexandra Serris, Amani Ouedrani, Fabrice Uhel, Marianne Gazzano, Vincent Bedarida, Claire Rouzaud, Marie‐Elisabeth Bougnoux, Jean‐Herlé Raphalen, S. Poirée, Olivier Lambotte, Guillaume Martin‐Blondel, Fanny Lanternier
Abstract
Invasive fungal diseases (IFD) still cause substantial morbidity and mortality, and new therapeutic approaches are urgently needed. Recent data suggest a benefit of checkpoint inhibitors (ICI). We report the case of a diabetic patient with refractory IFD following a SARSCoV-2 infection treated by ICI and interferon-gamma associated with antifungal treatment.
Topics & Concepts
Refractory (planetary science)MedicineMucormycosisAntifungalBlockadeAspergillosisImmunologyInterferonEchinocandinsIntensive care medicineAmphotericin BCaspofunginInternal medicineDermatologyBiologySurgeryAstrobiologyReceptorAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment