The Contribution of Lipotoxicity to Diabetic Kidney Disease
Jeffrey R. Schelling
Abstract
Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. This review highlights lipotoxicity pathways in the podocyte and proximal tubule cell, which are arguably the two most critical sites in the nephron for DKD. The discussion focuses on membrane transporters and lipid droplets, which represent potential therapeutic targets, as well as current and developing pharmacologic approaches to reduce renal lipotoxicity.
Topics & Concepts
LipotoxicityMedicineDiabetes mellitusDiabetic nephropathyKidney diseaseNephronDiseasePodocyteDistal convoluted tubuleInternal medicineKidneyEndocrinologyInsulin resistanceProteinuriaPancreatic function and diabetesLipid metabolism and biosynthesisLiver Disease Diagnosis and Treatment