hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis
Shan Li, Fangmin Song, Lei Xu, Jingtao Li, Li Fang, Huabing Tan
Abstract
function of hsa_circ_0004018 in CCl4-induced liver fibrosis mice. We also reveal that the hsa_circ_0004018/hsa-miR-660-3p/TEP1 axis contributes to the proliferation and activation of HSCs. In addition, the overexpression of hsa_circ_0004018 alleviated the progression of liver fibrosis. In conclusion, our study highlights hsa_circ_0004018 as a potential biomarker and therapeutic target for liver fibrosis.
Topics & Concepts
Hepatic stellate cellDownregulation and upregulationIn vivoLiver fibrosisFibrosisIn vitroCircular RNACancer researchCCL4TransfectionChemistryMolecular biologyBiologyMedicinePathologyGeneBiochemistryCarbon tetrachlorideBiotechnologyOrganic chemistryCircular RNAs in diseasesLiver Disease Diagnosis and TreatmentLiver physiology and pathology