Population Pharmacokinetic Modeling and Probability of Target Attainment of Ceftaroline in Brain and Soft Tissues
Victória Etges Helfer, Alexandre Prehn Zavascki, Markus Zeitlinger, Bibiana Verlindo de Araújo, Teresa Dalla Costa
Abstract
Ceftaroline, approved to treat skin infections and pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA), has been considered for the treatment of central nervous system (CNS) infections. A population pharmacokinetic (popPK) model was developed to describe ceftaroline soft tissue and cerebrospinal fluid (CSF) distributions and investigate the probability of target attainment (PTA) of the percentage of the dosing interval that the unbound drug concentration exceeded the MIC (% fT >MIC ) to treat MRSA infections.
Topics & Concepts
PharmacokineticsMedicineDosingAntibioticsCerebrospinal fluidPopulationStaphylococcus aureusPopulation pharmacokineticsPneumoniaMethicillin-resistant Staphylococcus aureusConfidence intervalPharmacologyInternal medicineIntensive care medicineMicrobiologyBiologyBacteriaGeneticsEnvironmental healthAntibiotics Pharmacokinetics and EfficacyAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility Testing