Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke
Hongcheng Luo, Tingzhuang Yi, Fugao Huang, Ying Wei, Xiaopeng Luo, Qisheng Luo
Abstract
experiments showed that MEG3 could specifically bind to miR-378 and subsequently up-regulate the expression of GRB2, which in turn suppressed the activation of Akt/mTOR pathway. Taken together, these findings suggested that miR-378 might protect against neuronal autophagy and neurological functional impairment and proposed that a MEG3/miR-378/GRB2 regulatory axis contributed to better understanding of the pathophysiology of ischemic stroke.
Topics & Concepts
AutophagyMEG3BiologyGene silencingPI3K/AKT/mTOR pathwayNeuroscienceCell biologyNeuronSignal transductionGeneLong non-coding RNADownregulation and upregulationBiochemistryApoptosisCancer-related molecular mechanisms researchAutophagy in Disease and TherapyMicroRNA in disease regulation