GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice
Fei Liu, Na Tian, Huaqiu Zhang, Shihong Li, Qiuzhi Zhou, Ying Yang, Jie Zheng, Jian‐Zhi Wang
Abstract
Early-stage activation of GSK-3β in NSCs impairs AHN by accelerating the depletion of NSC pool, and pharmacological inhibition of GSK-3β is efficient to preserve AHN during the accelerated aging. These results reveal novel mechanisms underlying the AHN impairments during accelerated senescence and provide new targets for pro-neurogenic therapies for related diseases.
Topics & Concepts
NeurogenesisHippocampal formationNeural stem cellNeuNSenescenceGSK3BGSK-3Glycogen synthaseBiologyCognitive declineCell biologyCancer researchMolecular biologyKinaseStem cellInternal medicineEndocrinologyMedicinePhosphorylationImmunologyImmunohistochemistryDementiaDiseaseNeurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation