Amphiphilic RGD and GHK peptides synergistically enhance liposomal delivery into cancer and endothelial cells
Mohamed Zoughaib, Rais V. Pavlov, Gulnara A. Gaynanova, Ruslan Garifullin, Vladimir G. Evtugyn, Timur I. Abdullin
Abstract
Combination of RGD cell adhesion peptide with GHK cell modulator peptide synergistically improves targeting of tumor cells. Amphiphilic peptides can be effectively displayed on liposomal surface for peptide screening and drug delivery applications.
Topics & Concepts
LiposomePeptideAmphiphileDrug deliveryCell-penetrating peptideCell adhesionCellAdhesionTargeted drug deliveryChemistryBiochemistryPharmacologyMedicineCopolymerOrganic chemistryPolymerRNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics