Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex
Anna M. Van Keuren, Chen-Wei Tsai, Enrique Balderas, Madison Rodriguez, Dipayan Chaudhuri, Ming-Feng Tsai
Abstract
without EMRE. We further show that EMRE may facilitate MCU opening by stabilizing the open state in a conserved MCU gating mechanism, present also in non-metazoan MCU homologs. These results provide insights into the evolution of the uniporter machinery and elucidate the mechanism underlying the physiologically crucial EMRE-dependent MCU activation process.
Topics & Concepts
UniporterProtein subunitGatingTransmembrane proteinMicrocontrollerBiophysicsChemistryBiologyCell biologyBiochemistryCytosolComputer scienceGeneReceptorComputer hardwareEnzymeMitochondrial Function and PathologyATP Synthase and ATPases ResearchTrace Elements in Health