In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets
Ziyi Zhang, Dalong Ni, Fei Wang, Xin Yin, Shreya Goel, Lazarus German, Yizhan Wang, Jun Li, Weibo Cai, Xudong Wang
Abstract
cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.
Topics & Concepts
Photodynamic therapySinglet oxygenNanomaterialsMaterials scienceIrradiationNanotechnologyCancer cellNanoparticleColloidal goldNanometreChemistryOxygenCancerComposite materialInternal medicineNuclear physicsMedicinePhysicsOrganic chemistryNanoplatforms for cancer theranosticsGold and Silver Nanoparticles Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis