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Myocarditis following mRNA vaccination against SARS-CoV-2, a case series

William King, Matthew Petersen, Ralph Matar, Jeffery Budweg, Lyda Cuervo Pardo, John W. Petersen

2021American Heart Journal Plus Cardiology Research and Practice38 citationsDOIOpen Access PDF

Abstract

INTRODUCTION: mRNA COVID-19 vaccines have emerged as a new form of vaccination that has proven to be highly safe and effective against COVID-19 vaccination. Rare adverse events including myocarditis have been reported in the literature. METHODS: Data were gathered from the electronic medical record of four patients personally treated by the authors. RESULTS: Four patients, ages 20 to 30, presented with myocarditis characterized by chest pain, elevations in troponin-I and C-reactive protein, and negative viral serologies two to four days following mRNA vaccine administration. One had a cardiac MRI showing delayed gadolinium enhancement in a subpericardial pattern. All experienced symptom resolution by the following day, and the two who have returned for follow-up had normal troponin-I and CRP values. DISCUSSION: Along with previously reported instances, these cases raise suspicion for a possible link between mRNA vaccines and myocarditis.

Topics & Concepts

MyocarditisVaccinationMedicineCoronavirus disease 2019 (COVID-19)Viral MyocarditisTroponinChest painInternal medicineCardiologyVirologyImmunologyPediatricsMyocardial infarctionInfectious disease (medical specialty)DiseaseViral Infections and Immunology ResearchSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies
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