Combining <i>in silico</i> and <i>in vitro</i> approaches to identify endogenous hypoglycemic peptides from human milk
Ting Xiao, Junpeng Zeng, Leyun Qiu, Ruiyan Wang, Nan Li, Zeyuan Deng, Liufeng Zheng
Abstract
one arene-H interaction, and GPR40 with Thr39, Ser41, Arg104, Arg2218 and Arg2221 residues through eight hydrogen interactions of its carbonyl groups and hydroxyl groups. The findings of this work open up the possibility of employing endogenous peptides from human milk as the hypoglycemic compounds for the prevention and treatment of diabetes.
Topics & Concepts
In silicoEndogenyChemistryIn vitroPeptideBiochemistryGlucose transporterGlucose uptakeInsulinBiologyEndocrinologyGeneInfant Nutrition and HealthProtein Hydrolysis and Bioactive PeptidesAdvanced Glycation End Products research