Laboratory Diagnosis of Creutzfeldt–Jakob Disease
Inga Zerr
Abstract
The diagnosis of Creutzfeldt–Jakob disease has advanced from detection of characteristic EEG and MRI features to include the detection in CSF of 14-3-3 protein and, with the use of RT-QuIC assays, of abnormally folded prion protein, with close to 100% sensitivity and specificity.
Topics & Concepts
MedicineCreutzfeldt-Jakob SyndromePrion proteinPathologyDiseaseVirologyElectroencephalographyPsychiatryPrion Diseases and Protein MisfoldingFibromyalgia and Chronic Fatigue Syndrome ResearchAlcoholism and Thiamine Deficiency