<scp>l</scp> -Proline-catalysed synthesis of chromeno[2,3- <i>b</i> ]chromene from 4-hydroxy-2 <i>H</i> -chromene-2-thione and an anti-proliferative study
Arnab Mandal, Satyajit Singh, Arisha Arora, Sujisha S Nambiar, Siddhartha Sankar Ghosh, Abu T. Khan
Abstract
-chromene-2-thione. In addition, a molecular docking study of all the derivatives was performed and among them, four compounds exhibited anti-proliferative activity and elevated ROS generation in breast cancer (MCF7) cell lines.
Topics & Concepts
ProlineChemistryStereochemistryMedicinal chemistryBiochemistryAmino acidMulticomponent Synthesis of HeterocyclesSynthesis of Organic CompoundsSynthesis and Characterization of Heterocyclic Compounds