Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production
Janne Tampio, Susanne Löffler, Melina Guillon, Agathe Hugele, Johanna Huttunen, Kristiina M. Huttunen
Topics & Concepts
MicrogliaProdrugPharmacologyKetoprofenChemistryViability assayIbuprofenProstaglandin E2Blood–brain barrierNaproxenInflammationProstaglandinLipopolysaccharideBiochemistryCellMedicineImmunologyCentral nervous systemInternal medicinePathologyAlternative medicineAmino Acid Enzymes and MetabolismNeuroscience and Neuropharmacology ResearchDrug Transport and Resistance Mechanisms