Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms
Connor J. Frapwell, Paul Skipp, R. P. Howlin, Elizabeth M. Angus, Yanmin Hu, Anthony Coates, R N Allan, Jeremy S. Webb
Abstract
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
Topics & Concepts
Staphylococcus aureusBiofilmMicrobiologyAntimicrobialQuinolineAntibioticsBiologyStaphylococcal infectionsBacteriaChemistryOrganic chemistryGeneticsAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensingAntibiotic Resistance in Bacteria