Functionalized hydrogel–microsphere composites stimulating neurite outgrowth for vascularized bone regeneration
Qian Li, He Zhang, Ziqian Zeng, Shuang Yan, Yu Hei, Yifei Zhang, Yang Chen, Siqi Zhang, Wen Zhou, Shicheng Wei, Yuhua Sun
Abstract
results show that the hydrogel-microsphere composites not only promote new bone formation, but also facilitate nerve infiltration and angiogenesis. Furthermore, the neurovascularized niche created by this composite stimulated neurite growth through MAPK, PI3K, IL17 and TNF signaling pathways, enabling vascularized bone regeneration. The findings suggest a novel bioengineering approach to guide the construction of neurovascularized bone repair materials, which is beneficial for achieving functional bone regeneration and repair.
Topics & Concepts
Regeneration (biology)NeuriteMicrosphereChemistrySelf-healing hydrogelsBiomedical engineeringComposite materialMaterials scienceCell biologyPolymer chemistryChemical engineeringIn vitroBiologyBiochemistryMedicineEngineeringBone Tissue Engineering MaterialsGraphene and Nanomaterials Applications3D Printing in Biomedical Research