Recent advances in the direct β-C(sp<sup>2</sup>)–H functionalization of enamides
Tong‐Hao Zhu, Shimin Xie, Pornchai Rojsitthisak, Jie Wu
Abstract
The direct β-C(sp2)-H functionalization of enamides has attracted increasing attention among the chemical community, due to the diverse biological and pharmaceutical activities of enamides. This review is focused on the recent advances in the direct β-C(sp2)-H functionalization of enamides, mainly including arylation, alkenylation, alkynylation, alkylation, acylation, sulfonylation, phosphorylation, and others. Additionally, mechanistic features of these transformations are also discussed.
Topics & Concepts
ChemistrySurface modificationCombinatorial chemistryNanotechnologyPhysical chemistryMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Synthesis and Catalysis