Nanoscale Metal–Organic Framework Confines Zinc-Phthalocyanine Photosensitizers for Enhanced Photodynamic Therapy
Taokun Luo, Geoffrey T. Nash, Ziwan Xu, Xiaomin Jiang, Jianqiao Liu, Wenbin Lin
Abstract
of 0.14 μM and achieved exceptional antitumor efficacy with >99% tumor growth inhibition and 80% cure rates on two murine colon cancer models.
Topics & Concepts
ChemistryPhotodynamic therapyZincPhthalocyanineQuenching (fluorescence)Conjugated systemPhotochemistryBiocompatibilityPhotosensitizerSolubilityAqueous solutionNanoscopic scaleReactive oxygen speciesBiophysicsNanotechnologyFluorescenceOrganic chemistryPolymerBiochemistryMaterials sciencePhysicsQuantum mechanicsBiologyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesMetal-Organic Frameworks: Synthesis and Applications