Dual ligand approach increases functional group tolerance in the Pd-catalysed C–H arylation of <i>N</i>-heterocyclic pharmaceuticals
Igor Beckers, Aram L. Bugaev, Dirk De Vos
Abstract
XAS measurements, confirming the coordination of both ligands under the reaction conditions. The C-H activation catalyst was shown to be tolerant to a wide range of pharmaceutically relevant scaffolds, including examples of late-stage functionalization of known drug molecules.
Topics & Concepts
Functional groupChemistryLigand (biochemistry)Dual (grammatical number)StereochemistryGroup (periodic table)Combinatorial chemistryMedicinal chemistryDual roleReceptorOrganic chemistryBiochemistryPolymerArtLiteratureCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis