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Molecular mechanisms of resveratrol and EGCG in the inhibition of Aβ<sub>42</sub> aggregation and disruption of Aβ<sub>42</sub> protofibril: similarities and differences

Fangying Li, Chendi Zhan, Xuewei Dong, Guanghong Wei

2021Physical Chemistry Chemical Physics52 citationsDOI

Abstract

protofibrils mainly via hydrogen-bonding and hydrophobic interactions. For comparison, we also explore the effects of RSV/EGCG molecules on the aggregation inhibition and protofibril disruption of the Iowa mutant (D23N) Aβ. Our findings may pave the way for the design of more effective drug candidates as well as the utilization of cocktail therapy using RSV and EGCG for the treatment of AD.

Topics & Concepts

FibrilChemistryResveratrolBiophysicsStackingMonomerHydrogen bondProtein aggregationCrystallographyBiochemistryMoleculeBiologyPolymerOrganic chemistryAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsBiochemical effects in animals
Molecular mechanisms of resveratrol and EGCG in the inhibition of Aβ<sub>42</sub> aggregation and disruption of Aβ<sub>42</sub> protofibril: similarities and differences | Litcius