IL-6 and other biomarkers as predictors of severity in COVID-19
Niklas Broman, Kaisa Rantasärkkä, Thijs Feuth, M. Valtonen, Matti Waris, Ulla Hohenthal, Esa Rintala, Antti Karlsson, Harri Marttila, Ville Peltola, Tytti Vuorinen, Jarmo Oksi
Abstract
OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS: Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS: IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.