Pegylated metal-free and zinc(<scp>ii</scp>) phthalocyanines: synthesis, photophysicochemical properties and<i>in vitro</i>photodynamic activities against head, neck and colon cancer cell lines
Berkay Akkoç, Taylan Samsunlu, Şeyma Işık, Mukaddes Özçeşmeci, Göknur Yaşa Atmaca, Alı Erdoğmuş, Müge Serhatlı, Esin Hamuryudan
Abstract
studies using the A253, FaDu (head and neck cancer cell lines), and HT29 (colon cancer) cell lines. The strongest photodynamic activity was found in 1b and 2b molecules with a metal core among the four molecules studied. The results suggested that the non-peripherally tetra-substituted 1b molecule was regarded as a suitable photodynamic therapy agent due to its light cytotoxicity and secondary impact induced by ROS production.
Topics & Concepts
Singlet oxygenPhthalocyaninePhthalonitrilePhotodynamic therapyZincChemistryMoleculeMetalPhotochemistryReactive oxygen speciesPolymer chemistryNuclear chemistryOxygenOrganic chemistryBiochemistryPorphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics