Electrochemical oxidative <i>Z</i>-selective C(sp<sup>2</sup>)–H chlorination of acrylamides
James Harnedy, Mishra Deepak Hareram, Graham J. Tizzard, Simon J. Coles, Louis C. Morrill
Abstract
-β-chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.
Topics & Concepts
ElectrochemistryOxidative phosphorylationChemistryMedicinal chemistryCombinatorial chemistryNuclear chemistryElectrodePhysical chemistryBiochemistryOxidative Organic Chemistry ReactionsRadical Photochemical ReactionsSynthesis and Catalytic Reactions