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Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake

Jeyun Jo, Dahae Lee, Yeong Hye Park, H.S. Choi, Jin‐Hee Han, Do Hwi Park, You-Kyung Choi, Jinsook Kwak, Min-Kyu Yang, Jin‐Wook Yoo, Hyung Ryong Moon, Dongho Geum, Ki Sung Kang, Hwayoung Yun

2021European Journal of Medicinal Chemistry18 citationsDOI

Topics & Concepts

ChemistryInsulinPyrazoleEffectorGlucose uptakeGlucose homeostasisC2C12CytotoxicitySecretionIRS1BiochemistryInternal medicineInsulin receptorEndocrinologyStereochemistryInsulin resistanceIn vitroBiologyMedicineMyogenesisPancreatic function and diabetesDiabetes Treatment and ManagementMetabolism, Diabetes, and Cancer
Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake | Litcius