Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK
Yuki Murata, Norio Harada, Shigenobu Kishino, Kanako Iwasaki, Eri Ikeguchi-Ogura, Shunsuke Yamane, Tomoko Kato, Yoshinori Kanemaru, Akiko Sankoda, Tomonobu Hatoko, Sakura Kiyobayashi, Jun Ogawa, Akira Hirasawa, Nobuya Inagaki
Abstract
-knockout mice. Thus, MCT-induced inhibition of GIP hypersecretion reduces obesity and insulin resistance under high-LCT diet feeding condition.
Topics & Concepts
EndocrinologyInternal medicineGastric inhibitory polypeptideSecretionTriglycerideInsulin resistanceCholecystokininChemistryMedium-chain triglycerideIngestionGPR120Enteroendocrine cellAgonistFatty acidInsulinBiologyReceptorCholesterolHormoneBiochemistryMedicineEndocrine systemG protein-coupled receptorGlucagonRegulation of Appetite and ObesityMetabolism, Diabetes, and CancerDiabetes Treatment and Management