Ruthenium(<scp>ii</scp>)-catalyzed regioselective direct C4- and C5-diamidation of indoles and mechanistic studies
Shreedhar Devkota, Suyeon Kim, Seok Yeol Yoo, Sonaimuthu Mohandoss, Mu‐Hyun Baik, Yong Rok Lee
Abstract
]thiophene-3-carboxaldehyde is a viable substrate and affords its corresponding diamidation products. The diamido indoles are further converted into various functionalized products and used as sensors for metal ion detection. Density functional theory studies are also conducted to propose a reaction mechanism and provide a detailed understanding of the regioselectivity observed in the reaction.
Topics & Concepts
RegioselectivityRutheniumCatalysisChemistryCombinatorial chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions