Curcumin exerts anti-tumor activity in colorectal cancer <i>via</i> gut microbiota-mediated CD8<sup>+</sup> T Cell tumor infiltration and ferroptosis
Hongli Zhou, Yu-Pei Zhuang, Yuwei Liang, Haibin Chen, Wenli Qiu, Huiqin Xu, Hongguang Zhou, Hongguang Zhou, Hongguang Zhou
Abstract
T cell tumor infiltration, and induced ferroptosis in tumor cells. Additionally, when gut microbiota was depleted with antibiotics, Cur's antitumor effects disappeared, suggesting that Cur mitigates CRC in a gut microbiota-dependent manner. These findings provide new insights into the mechanisms underlying CRC and propose novel therapeutic interventions, emphasizing the interaction between gut microbiota and immune responses within the tumor immune microenvironment (TIME).
Topics & Concepts
CurcuminColorectal cancerInfiltration (HVAC)Cancer researchCD8Gut floraCancerMedicineBiologyImmunologyImmune systemInternal medicinePharmacologyPhysicsThermodynamicsFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersMicroRNA in disease regulation