<i>Bifidobacterium lactis</i> BL-99 protects mice with osteoporosis caused by colitis <i>via</i> gut inflammation and gut microbiota regulation
Hui Lan, Wei‐Hsien Liu, Hanying Zheng, Haotian Feng, Wen Zhao, Wei‐Lian Hung, Hongwei Li
Abstract
< 0.05). Such probiotic supplementation also resulted in pronounced changes in the composition of the gut microbiota. Moreover, BL-99 intervention markedly increased the expression of intestinal barrier-related proteins (Claudin-1, MUC2, ZO-1, and Occludin). Together, these results suggest that BL-99 can be utilized as a beneficial probiotic preparation to prevent the incidence of osteoporosis in UC patients owing to its ability to shape the intestinal microflora and to suppress inflammatory cytokine production.
Topics & Concepts
Proinflammatory cytokineProbioticDysbiosisInflammatory bowel diseaseMedicineColitisInflammationGut floraOsteoporosisBifidobacteriumUlcerative colitisImmunologyInternal medicineLactobacillusBiologyDiseaseBacteriaGeneticsGut microbiota and healthInflammatory Bowel DiseaseBone Metabolism and Diseases