Electrifying P(V): Access to Polar and Radical Reactivity
Mahdi Jafarzadeh, Molhm Nassir, Luca Gherardi, Nicholas Raheja, Yu Kawamata, Phil S. Baran
Abstract
Electrochemical, fully stereoselective P(V)-radical hydrophosphorylation of olefins and carbonyl compounds using a P(V) reagent is disclosed. By strategically selecting the anode material, radical reactivity is accessible for alkene hydrophosphorylation whereas a polar pathway operates for ketone hydrophosphorylation. The mechanistic intricacies of these chemoselective transformations were explored in-depth.
Topics & Concepts
PolarReactivity (psychology)ChemistryPhysicsMedicineQuantum mechanicsPathologyAlternative medicineAmmonia Synthesis and Nitrogen ReductionMolecular Junctions and NanostructuresElectrocatalysts for Energy Conversion