Deletion of Double Copies of the US1 Gene Reduces the Infectivity of Recombinant Duck Plague Virus <i>In Vitro</i> and <i>In Vivo</i>
Ying Wu, Silun Tan, Qing He, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian, Anchun Cheng
Abstract
. This insight defines a fundamental role of the US1 gene in DPV infection and indicates its involvement in DPV transcription. These results provide clues for the study of the pathogenesis of the US1 gene and the development of attenuated vaccines targeting this gene.
Topics & Concepts
InfectivityVirologyBiologyRecombinant DNAIn vitroIn vivoVirusGenePlague (disease)GeneticsMedicinePathologyHerpesvirus Infections and TreatmentsMosquito-borne diseases and controlToxoplasma gondii Research Studies