Metal-free construction of dihydropyrazino[2,3-<i>b</i>]indoles from 2-aminoacetophenones, isocyanates and 1,2-diamines
Jingxi Fang, Jiayao Fang, Yingbo Rao, Huanyi Qiu, Zhentao Pan, Yongmin Ma
Abstract
]indoles (42 examples, 61-85% yields) were synthesized under mild conditions, even on a gram scale. This protocol features organocatalysts, an eco-friendly solvent, mild conditions, readily accessible substrates, broad substrate scope and simple work-up.
Topics & Concepts
MetalChemistryPolymer chemistryPolymer scienceOrganic chemistrySynthesis and Biological EvaluationMulticomponent Synthesis of HeterocyclesCatalytic C–H Functionalization Methods