Enhancing cell membrane phase separation for inhibiting cancer metastasis with a stimuli-responsive DNA nanodevice
Yingying Su, Xiaoqing Chen, Hui Wang, Lele Sun, Ying Xu, Di Li
Abstract
A DNA nanodevice is developed to enhance the cell membrane phase separation in a tumor microenvironment to weaken the formation of focal adhesion. As a result, the migration of cancer cells is inhibited both in vitro and in vivo .
Topics & Concepts
NanodeviceTransmembrane proteinCell biologyLipid raftCell membraneCell surface receptorMembraneBiophysicsCellSignal transductionChemistryBiologyReceptorBiochemistryMaterials scienceNanotechnologyNanopore and Nanochannel Transport StudiesRNA Interference and Gene DeliveryLipid Membrane Structure and Behavior