Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways
George F. Pavis, Tom S. O. Jameson, Marlou L. Dirks, Benjamin P. Lee, Doaa R. Abdelrahman, Andrew J. Murton, Craig Porter, Nima Alamdari, Catherine R. Mikus, Benjamin T. Wall, Francis B. Stephens
Abstract
The present study investigated the contribution of myofibrillar protein synthesis (MyoPS) and associated gene signaling to recovery from 300 muscle-damaging, eccentric contractions. Measured with D 2 O, MyoPS rates were elevated during recovery and observed alongside expression of inflammatory and regenerative signaling pathways. A nutritional intervention accelerated recovery; however, MyoPS and gene signaling were unchanged compared with placebo. These data indicate that MyoPS and associated signaling do not explain accelerated recovery from muscle damage.