Multilayer and MATR3-dependent regulation of mRNAs maintains pluripotency in human induced pluripotent stem cells
Daniele Pollini, Rosa Loffredo, Federica Maniscalco, Marina Cardano, Mariachiara Micaelli, Isabelle Bonomo, Nausicaa Valentina Licata, Daniele Peroni, Weronika Tomaszewska, Annalisa Rossi, V. Crippa, Erik Dassi, Gabriella Viero, Alessandro Quattrone, Angelo Poletti, Luciano Conti, Alessandro Provenzani
Abstract
promoters favoring their expression. YTHDF1, in turn, binds the m6A-modified OCT4 mRNA. Furthermore, MATR3 is recruited on ribosomes and controls pluripotency regulating the translation of specific transcripts, including NANOG and LIN28A, by direct binding and favoring their stabilization. These results show that MATR3 orchestrates the pluripotency circuitry by regulating the transcription, translational efficiency, and epitranscriptome of specific transcripts.