Saturated fat ingestion stimulates proatherogenic inflammation in polycystic ovary syndrome
Frank González, Robert V. Considine, Ola A. Abdelhadi, Jiaping Xue, Anthony J. Acton
Abstract
This paper demonstrates that in polycystic ovary syndrome (PCOS), ingestion of saturated fat triggers a molecular pathway of inflammation known to drive atherogenesis. This effect is independent of obesity as it occurs in lean women with PCOS and not in lean ovulatory control subjects. Furthermore, the combined effects of PCOS and obesity are greater compared with obesity alone.
Topics & Concepts
Polycystic ovaryIngestionInternal medicineEndocrinologyInflammationObesityMedicineOvaryInsulin resistanceOvarian function and disordersLipid metabolism and disordersCardiovascular Disease and Adiposity