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Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus

Fabio Del Bello, Alessandro Bonifazi, Gianfabio Giorgioni, Alessandro Piergentili, Maria Giovanna Sabbieti, Dimitrios Agas, Marzia Dell’Aera, Rosanna Matucci, Marcin Górecki, Gennaro Pescitelli, Giulio Vistoli, Wilma Quaglia

2020Journal of Medicinal Chemistry18 citationsDOIOpen Access PDF

Abstract

receptors are involved.

Topics & Concepts

ChemistryMuscarinic acetylcholine receptorMoietyStereochemistrySelectivityAntagonistDocking (animal)EnantiomerReceptorBiochemistryMedicineNursingCatalysisReceptor Mechanisms and SignalingCardiac electrophysiology and arrhythmiasIon channel regulation and function
Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus | Litcius