Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease
Yaoyang Liu, Chao Ma, Ying-Bo Li, Mengzhen Li, Mengzhen Li, Xueqi Zhao, Zhenli Li, Hongwei Jia, Hanxun Wang, Xiaomeng Xiu, Dexiang Hu, Ruiwen Zhang, Ningwei Wang, Peng Liu, Huali Yang, Maosheng Cheng, Maosheng Cheng
Topics & Concepts
TacrineChemistryCholinesteraseButyrylcholinesteraseAcetylcholinesterasePharmacologyRivastigmineIn vivoNeurotoxicityIC50OrganophosphateAchéBiochemistryToxicityIn vitroEnzymeDonepezilMedicineInternal medicineBiologyDementiaOrganic chemistryPesticideBiotechnologyAgronomyDiseaseCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments