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Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease

Yaoyang Liu, Chao Ma, Ying-Bo Li, Mengzhen Li, Mengzhen Li, Xueqi Zhao, Zhenli Li, Hongwei Jia, Hanxun Wang, Xiaomeng Xiu, Dexiang Hu, Ruiwen Zhang, Ningwei Wang, Peng Liu, Huali Yang, Maosheng Cheng, Maosheng Cheng

2023European Journal of Medicinal Chemistry23 citationsDOIOpen Access PDF

Topics & Concepts

TacrineChemistryCholinesteraseButyrylcholinesteraseAcetylcholinesterasePharmacologyRivastigmineIn vivoNeurotoxicityIC50OrganophosphateAchéBiochemistryToxicityIn vitroEnzymeDonepezilMedicineInternal medicineBiologyDementiaOrganic chemistryPesticideBiotechnologyAgronomyDiseaseCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments
Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo-irreversible cholinesterase inhibitors for the treatment of Alzheimer's disease | Litcius