Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity
Chengze Tian, Chengbin Yang, Tianze Wu, Mingzhu Lu, Yi Chen, Yongtai Yang, Xiaofeng Liu, Yun Ling, Mingli Deng, Jia Yu, Yaming Zhou
Topics & Concepts
CinnolinePharmacophoreChemistryPotencyIC50StereochemistryEnzymeStructure–activity relationshipIn vitroPharmacologyBiochemistryCombinatorial chemistryMedicinal chemistryMedicinePI3K/AKT/mTOR signaling in cancerSynthesis of Organic CompoundsCancer therapeutics and mechanisms