Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice
Martina Comelli, Marianna Meo, Daniel O. Cervantes, Emanuele Pizzo, Aaron Plosker, Peter J. Mohler, Thomas J. Hund, Jason T. Jacobson, Olivier Meste, Marcello Rota
Abstract
We have investigated age-associated alterations of heart rate properties in mice using conscious electrocardiographic recordings. Our findings support the notion that aging is coupled with altered sympathovagal balance with consequences on heart rate variability. Moreover, by using a genetically engineered mouse line, we provide evidence that sodium channels modulate heart rate and its age-related adaptations.
Topics & Concepts
Heart rateRhythmHeart RhythmBalance (ability)Heart rate variabilityCardiologyInternal medicineNeuroscienceDynamics (music)MedicinePsychologyBlood pressurePedagogyHeart Rate Variability and Autonomic ControlCircadian rhythm and melatoninStress Responses and Cortisol