A tris(benzyltriazolemethyl)amine-based cage as a CuAAC ligand tolerant to exogeneous bulky nucleophiles
Gege Qiu, Paola Nava, Alexandre Martinez, Cédric Colomban
Abstract
The canonical CuAAC–ligand<bold>TBTA</bold>was capped with a bowl-shaped unit yielding the cage<bold>Hm-TBTA</bold>. The shielded structure does not suffer from product inhibition effect and is remarkably tolerant to the biological CuAAC-inhibitor Glutathione.
Topics & Concepts
TrisLigand (biochemistry)ChemistryNucleophileAmine gas treatingCageGlutathioneBiophysicsCombinatorial chemistryStereochemistryBiochemistryBiologyOrganic chemistryReceptorCatalysisMathematicsEnzymeCombinatoricsClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniquesAdenosine and Purinergic Signaling