Sanger’s Reagent Sensitized Photocleavage of Amide Bond for Constructing Photocages and Regulation of Biological Functions
Tingwen Wei, Sheng Lu, Jia-Hui Sun, Zhijun Xu, Xiao Yang, Fang Wang, Yang Ma, Yun Stone Shi, Xiaoqiang Chen
Abstract
-methyl-d-aspartate receptors (NMDARs), and pulse rate of cardiomyocytes. The successful proof-of-concept examples described above open a new avenue for using Sanger's reagent-based glycine amides as photocages for the exploration of complex cellular functions and signaling pathways.
Topics & Concepts
ChemistryReagentCombinatorial chemistryDecarboxylationPeptide bondAmideCarbonic anhydraseBenzimidazoleMethyleneStereochemistryEnzymeMedicinal chemistryBiochemistryOrganic chemistryCatalysisPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchbioluminescence and chemiluminescence research