Collaborative Delirium Prevention in the Age of <scp>COVID</scp> ‐19

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented threat to all of us, regardless of age, nationality, or socioeconomic status. However, older patients are especially at risk for life-threatening respiratory, cardiovascular, and cerebral complications.1 As the COVID-19 pandemic continues to consume available global hospital resources, including in the United States, delirium prevention strategies may become an unintended casualty of scarce resource and personnel allocation.2 A significant consequence of these realities is an anticipated surge of delirium incidence and duration in hospitalized patients, regardless of COVID-19 status, due to increased risk factors and barriers to implementation of evidence-based delirium prevention guidelines.3, 4 An increase in delirium will result in both inadvertent harm to individuals and also exacerbation of hospital resource shortages.3, 4 Our goals are to highlight this insidious complication and pose pragmatic recommendations for minimizing the risk and duration of delirium in all patients during the COVID-19 pandemic. Even in the absence of drastic environmental modifications resulting from isolation and personal protective equipment (PPE) shortages, up to 50% to 70% of critically ill patients, and 10% to 15% of hospitalized general medical patients, develop delirium.3, 5 Compared with non-delirious patients, delirious patients are more likely to consume more hospital staff time and precious life-support resources, stay longer, and develop in-hospital complications. Higher rates of delirium will also likely result in more patients discharged to a facility and readmitted to the hospital.6 Such complications would greatly stress an already chaotic healthcare system during the COVID-19 pandemic. Delirium is not inevitable; rather, it is preventable in approximately 30% to 40% of cases.3 Unfortunately, the COVID-19 management issues outlined in Table 1 bring to light potential barriers to our typical nonpharmacologic prevention strategies such as the Assess, Prevent, and Manage Pain, Both Spontaneous Awakening Trials and Spontaneous Breathing Trials, Choice of analgesia and sedation, Delirium: Assess, Prevent, and Manage, Early mobility and Exercise, and Family engagement and empowerment (ABCDEF) bundle in the intensive care unit (ICU)7 or the Hospital Elder Life Program.8 These interventions target risk factors for delirium including inadequate pain management, overuse of sedation and time on mechanical ventilation, restraints, social isolation from loved ones, immobility, and sleep disruption.7, 8 Delirium prevention programs are even more crucial in the era of COVID-19 and cannot be allowed to wither despite the challenges of integrating delirium prevention with COVID-19 care. Visitors are now prohibited for all hospitalized patients, with rare exceptions.9 Because we know that caregivers play pivotal roles in delirium prevention by reducing isolation, providing daytime stimulation to maintain sleep-wake cycles, and advocating for patient needs,10 excluding them is likely to exacerbate rates of delirium, posttraumatic stress disorder, and depression. For this reason, we posit that caregivers, even if family members or friends, are essential healthcare workers because they can prevent these poor clinical outcomes.11 We believe that a designated caregiver should be allowed to accompany a non-COVID patient with cognitive impairment or delirium during hospitalization, provided the caregiver passes the hospital health screen and wears a mask. Patients hospitalized with COVID-19 face additional challenges (outlined in Table 1). Those who are critically ill, requiring ICU-level care, are most at risk of developing delirium. Those who improve may be transferred out of the ICU still delirious. Tests often occur late at night to ensure adequate time for equipment sterilization, disrupting sleep and causing disorientation for vulnerable patients. In addition to being isolated from visitors, these patients also have minimal contact with staff, including nursing and rehabilitation services, largely to preserve PPE and reduce exposure. Although created with the intention of minimizing contagion, policies that increase isolation and immobility for hospitalized patients, combined with acute illness, produce a high-risk environment for delirium.3 We propose several strategies for delirium prevention adapted during this critical time that require minimal effort to implement and do not increase risk of exposure to healthcare workers (Table 1). We highlight meaningful steps that can occur outside patient rooms, as well as low-tech ways for improving communication that is hindered by PPE. We also propose ways to integrate technology into the workflow to reduce the isolation felt between patients and family members. Mitigating delirium during this chaotic time is possible with interdisciplinary teamwork and flexibility of roles. Some might think that infection with the SARS-CoV-2 virus has created a new reality in the field of healthcare that would allow us to triage delirium “off the table” as a priority. We believe the opposite is true. A focus on delirium during the COVID-19 pandemic is more important than ever. Millions of people are at risk for delirium as a complementary and exacerbating factor of COVID-19. Doubling down on established protocols and guidelines for delirium prevention and management will help with our ventilator and hospital bed shortage. Delirium prevention tenets are not antithetical to the precautions needed to care for patients in a pandemic. Rather, these principles center on the humanistic qualities that inspired many of us to enter medicine in the first place. While faced with unprecedented social isolation, preventing delirium in our patients is something we must all embrace. The authors have declared no conflicts of interest for this article. Sara C. LaHue drafted the article. All the authors made substantial contributions to the conception and design, revised the article critically for important intellectual content, and approved the final version to be published. No sponsor to report.

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