CDC20: a novel therapeutic target in cancer.
Wenning He, Jun Meng
Abstract
, which destroys key regulators of the cell cycle and promotes mitosis. Cdc20 serves as a target for the spindle checkpoint, ensuring proper chromosome segregation. As an oncoprotein, Cdc20 is highly expressed in a variety of malignant tumors, and Cdc20 overexpression is associated with poor prognosis of these tumors. This review aims to dissect the tumorigenic role of Cdc20 in human malignancies and its targeting strategies.
Topics & Concepts
CDC20Anaphase-promoting complexMitosisSpindle checkpointUbiquitin ligaseCancer researchCell cycle checkpointCell cycleBiologyCyclin D1Cell biologyCyclin BCancerAnaphaseCell divisionCellUbiquitinGeneticsSpindle apparatusGeneMicrotubule and mitosis dynamicsUbiquitin and proteasome pathwaysCancer-related Molecular Pathways